{"id":38783,"date":"2026-06-11T11:04:11","date_gmt":"2026-06-11T07:34:11","guid":{"rendered":"https:\/\/www.abtaab.ir\/?p=38783"},"modified":"2026-06-12T11:05:03","modified_gmt":"2026-06-12T07:35:03","slug":"%d8%a8%db%8c%d9%85%d8%a7%d8%b1%db%8c-%d9%86%d8%a7%d8%af%d8%b1-%da%98%d9%86%d8%aa%db%8c%da%a9%db%8c-%da%a9%d9%85%d8%a8%d9%88%d8%af-cps1-%d9%88-%d8%af%d8%b1%d9%85%d8%a7%d9%86-%d9%86%d9%88","status":"publish","type":"post","link":"https:\/\/www.abtaab.ir\/?p=38783","title":{"rendered":"\u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u0627\u062f\u0631 \u0698\u0646\u062a\u06cc\u06a9\u06cc \u00ab\u06a9\u0645\u0628\u0648\u062f CPS1\u00bb \u0648 \u062f\u0631\u0645\u0627\u0646 \u0646\u0648\u06cc\u0646 \u0622\u0646"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"><span style=\"color: #0000ff;\"><strong>\u0622\u0628\u062a\u0627\u0628: <\/strong><span style=\"color: #000000;\">\u062f\u06a9\u062a\u0631 \u0645\u062d\u0645\u062f\u0639\u0644\u06cc \u0635\u0627\u0631\u0645\u06cc\u060c<\/span><\/span>\u00a0\u062f\u0631 \u0645\u06cc\u0627\u0646 \u0647\u0632\u0627\u0631\u0627\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u0627\u062f\u0631 \u0698\u0646\u062a\u06cc\u06a9\u06cc \u06a9\u0647 \u0647\u0631 \u06cc\u06a9 \u0628\u0647 \u062a\u0646\u0647\u0627\u06cc\u06cc \u062a\u0639\u062f\u0627\u062f \u0645\u062d\u062f\u0648\u062f\u06cc \u0627\u0632 \u0627\u0641\u0631\u0627\u062f \u0631\u0627 \u062f\u0631 \u0633\u0631\u0627\u0633\u0631 \u062c\u0647\u0627\u0646 \u062a\u062d\u062a \u062a\u0623\u062b\u06cc\u0631 \u0642\u0631\u0627\u0631 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f\u060c \u00ab\u06a9\u0645\u0628\u0648\u062f \u0622\u0646\u0632\u06cc\u0645 \u06a9\u0631\u0628\u0627\u0645\u0648\u0626\u06cc\u0644 \u0641\u0633\u0641\u0627\u062a \u0633\u0646\u062a\u062a\u0627\u0632 \u06f1\u00bb \u06cc\u0627 \u0628\u0647 \u0627\u062e\u062a\u0635\u0627\u0631 CPS1 deficiency \u06cc\u06a9\u06cc \u0627\u0632 \u067e\u06cc\u0686\u06cc\u062f\u0647\u200c\u062a\u0631\u06cc\u0646 \u0648 \u062e\u0637\u0631\u0646\u0627\u06a9\u200c\u062a\u0631\u06cc\u0646 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u06a9 \u0645\u062d\u0633\u0648\u0628 \u0645\u06cc\u200c\u0634\u0648\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0628\u0647 \u062f\u0633\u062a\u0647\u200c\u0627\u06cc \u0627\u0632 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0628\u0647 \u0646\u0627\u0645 \u00ab\u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0686\u0631\u062e\u0647 \u0627\u0648\u0631\u0647\u00bb \u062a\u0639\u0644\u0642 \u062f\u0627\u0631\u062f \u06a9\u0647 \u062f\u0631 \u0622\u0646 \u0622\u0646\u0632\u06cc\u0645\u200c\u0647\u0627\u06cc \u06a9\u0628\u062f\u06cc \u0642\u0627\u062f\u0631 \u0628\u0647 \u062a\u0628\u062f\u06cc\u0644 \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 \u0633\u0645\u06cc \u0628\u0647 \u0627\u0648\u0631\u0647 \u0646\u06cc\u0633\u062a\u0646\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">CPS1 \u0622\u0646\u0632\u06cc\u0645\u06cc \u06a9\u0644\u06cc\u062f\u06cc \u062f\u0631 \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u06a9\u0628\u062f \u0627\u0633\u062a \u06a9\u0647 \u0648\u0638\u06cc\u0641\u0647 \u0622\u063a\u0627\u0632 \u0641\u0631\u0622\u06cc\u0646\u062f \u062f\u0641\u0639 \u0646\u06cc\u062a\u0631\u0648\u0698\u0646 \u0627\u0636\u0627\u0641\u06cc \u062d\u0627\u0635\u0644 \u0627\u0632 \u062a\u062c\u0632\u06cc\u0647 \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u200c\u0647\u0627 \u0631\u0627 \u0628\u0631 \u0639\u0647\u062f\u0647 \u062f\u0627\u0631\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u062f\u0631 \u0627\u0641\u0631\u0627\u062f \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u06a9\u0645\u0628\u0648\u062f CPS1 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u062c\u0647\u0634 \u062f\u0631 \u0698\u0646 CPS1\u060c \u0627\u06cc\u0646 \u0622\u0646\u0632\u06cc\u0645 \u0628\u0647 \u0645\u06cc\u0632\u0627\u0646 \u06a9\u0627\u0641\u06cc \u062a\u0648\u0644\u06cc\u062f \u0646\u0645\u06cc\u200c\u0634\u0648\u062f \u0648 \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 \u06a9\u0647 \u0645\u0627\u062f\u0647 \u0627\u06cc \u0628\u0633\u06cc\u0627\u0631 \u0633\u0645\u06cc \u0628\u0631\u0627\u06cc \u0633\u0644\u0648\u0644\u200c\u0647\u0627\u06cc \u0639\u0635\u0628\u06cc \u0627\u0633\u062a\u060c \u0628\u0647 \u0633\u0631\u0639\u062a \u062f\u0631 \u062e\u0648\u0646 \u0648 \u0628\u0627\u0641\u062a\u200c\u0647\u0627 \u062a\u062c\u0645\u0639 \u0645\u06cc\u200c\u06cc\u0627\u0628\u062f \u0648 \u0622\u0633\u06cc\u0628\u200c\u0647\u0627\u06cc \u062c\u0628\u0631\u0627\u0646\u200c\u0646\u0627\u067e\u0630\u06cc\u0631 \u0648 \u06af\u0627\u0647 \u06a9\u0634\u0646\u062f\u0647\u200c\u0627\u06cc \u0628\u0647 \u0645\u063a\u0632 \u0648 \u06a9\u0628\u062f \u0648\u0627\u0631\u062f \u0645\u06cc\u200c\u06a9\u0646\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0622\u0646\u0642\u062f\u0631 \u0646\u0627\u062f\u0631 \u0627\u0633\u062a \u06a9\u0647 \u0627\u0632 \u0647\u0631 \u06cc\u06a9 \u0645\u06cc\u0644\u06cc\u0648\u0646 \u0646\u0648\u0632\u0627\u062f\u060c \u0627\u062d\u062a\u0645\u0627\u0644\u0627\u064b \u062a\u0646\u0647\u0627 \u06cc\u06a9 \u06cc\u0627 \u062f\u0648 \u0646\u0641\u0631 \u0628\u0627 \u0634\u06a9\u0644 \u0634\u062f\u06cc\u062f \u0622\u0646 \u0645\u062a\u0648\u0644\u062f \u0645\u06cc\u200c\u0634\u0648\u0646\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0634\u06cc\u0648\u0639 \u0648\u0627\u0642\u0639\u06cc \u0622\u0646 \u0646\u0627\u0634\u0646\u0627\u062e\u062a\u0647 \u0627\u0633\u062a\u060c 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\u062d\u0627\u0644 \u0631\u0634\u062f \u0622\u0646\u200c\u0647\u0627 \u062f\u0631 \u0628\u0631\u0627\u0628\u0631 \u0633\u0637\u0648\u062d \u0628\u0627\u0644\u0627\u06cc \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 \u0628\u0647 \u0634\u062f\u062a \u0622\u0633\u06cc\u0628\u200c\u067e\u0630\u06cc\u0631 \u0627\u0633\u062a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0639\u0644\u0627\u0626\u0645 \u0628\u0627\u0644\u06cc\u0646\u06cc \u06a9\u0645\u0628\u0648\u062f CPS1 \u0645\u0639\u0645\u0648\u0644\u0627\u064b \u062f\u0631 \u0631\u0648\u0632\u0647\u0627 \u06cc\u0627 \u0647\u0641\u062a\u0647\u200c\u0647\u0627\u06cc \u0627\u0648\u0644 \u067e\u0633 \u0627\u0632 \u062a\u0648\u0644\u062f \u0648 \u0628\u0627 \u0634\u0631\u0648\u0639 \u062a\u063a\u0630\u06cc\u0647 \u0628\u0627 \u0634\u06cc\u0631\u062e\u0634\u06a9 \u06cc\u0627 \u0634\u06cc\u0631 \u0645\u0627\u062f\u0631 \u06a9\u0647 \u062d\u0627\u0648\u06cc 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\u0645\u0627\u062f\u0627\u0645\u200c\u0627\u0644\u0639\u0645\u0631 \u06af\u0631\u062f\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u062f\u0631 \u0627\u0634\u06a9\u0627\u0644 \u062e\u0641\u06cc\u0641\u200c\u062a\u0631 \u0648 \u0628\u0627 \u0634\u0631\u0648\u0639 \u062f\u06cc\u0631\u062a\u0631\u060c \u0639\u0644\u0627\u0626\u0645 \u0645\u0645\u06a9\u0646 \u0627\u0633\u062a \u0634\u0627\u0645\u0644 \u0628\u06cc\u0632\u0627\u0631\u06cc \u0627\u0632 \u063a\u0630\u0627\u0647\u0627\u06cc \u067e\u0631\u0648\u062a\u0626\u06cc\u0646\u06cc\u060c \u0639\u0642\u0628\u200c\u0645\u0627\u0646\u062f\u06af\u06cc \u0631\u0634\u062f\u060c \u0628\u0632\u0631\u06af\u200c\u0634\u062f\u0646 \u06a9\u0628\u062f \u0648 \u062d\u0645\u0644\u0627\u062a \u0645\u06a9\u0631\u0631 \u06af\u06cc\u062c\u06cc \u0648 \u062e\u0648\u0627\u0628\u200c\u0622\u0644\u0648\u062f\u06af\u06cc \u0628\u0627\u0634\u062f \u06a9\u0647 \u0627\u063a\u0644\u0628 \u0628\u0627 \u0639\u0641\u0648\u0646\u062a\u200c\u0647\u0627\u06cc \u0633\u0627\u062f\u0647 \u06cc\u0627 \u0631\u0648\u0632\u0647\u200c\u062f\u0627\u0631\u06cc \u062a\u062d\u0631\u06cc\u06a9 \u0645\u06cc\u200c\u0634\u0648\u0646\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u062a\u0634\u062e\u06cc\u0635 \u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0639\u0645\u062f\u062a\u0627\u064b \u0627\u0632 \u0637\u0631\u06cc\u0642 \u0627\u0646\u062f\u0627\u0632\u0647\u200c\u06af\u06cc\u0631\u06cc \u0633\u0637\u062d \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 \u067e\u0644\u0627\u0633\u0645\u0627\u060c \u0622\u0646\u0627\u0644\u06cc\u0632 \u0627\u0633\u06cc\u062f\u0647\u0627\u06cc \u0622\u0645\u06cc\u0646\u0647 \u062e\u0648\u0646 \u0648 \u0627\u062f\u0631\u0627\u0631 \u0648 \u0646\u0647\u0627\u06cc\u062a\u0627\u064b \u0628\u0627 \u062a\u0633\u062a\u200c\u0647\u0627\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0628\u0631\u0627\u06cc \u06cc\u0627\u0641\u062a\u0646 \u062c\u0647\u0634 \u062f\u0631 \u0698\u0646 CPS1 \u0627\u0646\u062c\u0627\u0645 \u0645\u06cc\u200c\u0634\u0648\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0647\u0631\u0686\u0646\u062f \u063a\u0631\u0628\u0627\u0644\u06af\u0631\u06cc \u0646\u0648\u0632\u0627\u062f\u0627\u0646 \u0628\u0631\u0627\u06cc \u0647\u0645\u0647 \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0686\u0631\u062e\u0647 \u0627\u0648\u0631\u0647 \u0647\u0646\u0648\u0632 \u062f\u0631 \u0628\u0633\u06cc\u0627\u0631\u06cc \u0627\u0632 \u06a9\u0634\u0648\u0631\u0647\u0627 \u0631\u0627\u06cc\u062c \u0646\u06cc\u0633\u062a\u060c \u0627\u0645\u0627 \u062f\u0631 \u0634\u06cc\u0631\u062e\u0648\u0627\u0631\u0627\u0646\u06cc \u06a9\u0647 \u0628\u0627 \u0639\u0644\u0627\u0626\u0645 \u0645\u0634\u06a9\u0648\u06a9 \u0645\u0631\u0627\u062c\u0639\u0647 \u0645\u06cc\u200c\u06a9\u0646\u0646\u062f\u060c \u0627\u0646\u062f\u0627\u0632\u0647\u200c\u06af\u06cc\u0631\u06cc \u0627\u0648\u0631\u0698\u0627\u0646\u0633\u06cc \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 \u062e\u0648\u0646 \u06cc\u06a9 \u062a\u0633\u062a \u062d\u06cc\u0627\u062a\u06cc \u0648 \u0646\u062c\u0627\u062a\u200c\u0628\u062e\u0634 \u0627\u0633\u062a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0645\u062a\u0623\u0633\u0641\u0627\u0646\u0647 \u0628\u0647 \u062f\u0644\u06cc\u0644 \u0646\u0627\u062f\u0631 \u0628\u0648\u062f\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0648 \u062a\u0634\u0627\u0628\u0647 \u0639\u0644\u0627\u0626\u0645 \u0627\u0648\u0644\u06cc\u0647 \u0622\u0646 \u0628\u0627 \u0633\u067e\u0633\u06cc\u0633 \u06cc\u0627 \u0633\u0627\u06cc\u0631 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u06a9\u060c \u0627\u063a\u0644\u0628 \u062a\u0634\u062e\u06cc\u0635 \u0628\u0627 \u062a\u0623\u062e\u06cc\u0631 \u0635\u0648\u0631\u062a \u0645\u06cc\u200c\u06af\u06cc\u0631\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0627\u0645\u0627 \u0628\u0632\u0631\u06af\u200c\u062a\u0631\u06cc\u0646 \u0646\u0642\u0637\u0647 \u0627\u0645\u06cc\u062f \u062f\u0631 \u062f\u0631\u0645\u0627\u0646 \u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u06a9\u0627\u0628\u0648\u0633\u200c\u0648\u0627\u0631\u060c \u062a\u062d\u0648\u0644\u06cc \u0627\u0633\u062a \u06a9\u0647 \u062f\u0631 \u0639\u0631\u0635\u0647 \u0698\u0646 \u062f\u0631\u0645\u0627\u0646\u06cc \u0631\u062e \u062f\u0627\u062f\u0647 \u0627\u0633\u062a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u062a\u0627 \u067e\u06cc\u0634 \u0627\u0632 \u0633\u0627\u0644\u200c\u0647\u0627\u06cc \u0627\u062e\u06cc\u0631\u060c \u062f\u0631\u0645\u0627\u0646 \u0627\u0633\u062a\u0627\u0646\u062f\u0627\u0631\u062f \u06a9\u0645\u0628\u0648\u062f CPS1 \u0645\u0646\u062d\u0635\u0631\u0627\u064b \u0634\u0627\u0645\u0644 \u06cc\u06a9 \u0631\u0698\u06cc\u0645 \u063a\u0630\u0627\u06cc\u06cc \u0641\u0648\u0642 \u0627\u0644\u0639\u0627\u062f\u0647 \u0633\u062e\u062a \u0648 \u06a9\u0645\u200c\u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u0647\u0645\u0631\u0627\u0647 \u0628\u0627 \u0645\u0635\u0631\u0641 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc\u06cc \u0628\u0631\u0627\u06cc \u062c\u0630\u0628 \u0648 \u062f\u0641\u0639 \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 (\u0645\u0627\u0646\u0646\u062f \u0641\u0646\u06cc\u0644 \u0628\u0648\u062a\u06cc\u0631\u0627\u062a \u0633\u062f\u06cc\u0645 \u0648 \u0622\u0631\u0698\u06cc\u0646\u06cc\u0646) \u0628\u0648\u062f \u062a\u0627 \u06a9\u0648\u062f\u06a9 \u0628\u0647 \u0633\u0646\u06cc \u0628\u0631\u0633\u062f \u06a9\u0647 \u0628\u062a\u0648\u0627\u0646\u062f \u067e\u06cc\u0648\u0646\u062f \u06a9\u0628\u062f \u0627\u0646\u062c\u0627\u0645 \u062f\u0647\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u067e\u06cc\u0648\u0646\u062f \u06a9\u0628\u062f \u0639\u0645\u0644\u0627\u064b \u0646\u0642\u0635 \u0622\u0646\u0632\u06cc\u0645\u06cc \u0631\u0627 \u0628\u0631\u0637\u0631\u0641 \u0645\u06cc\u200c\u06a9\u0646\u062f\u060c \u0627\u0645\u0627 \u062f\u0648\u0631\u0627\u0646 \u0627\u0646\u062a\u0638\u0627\u0631 \u0628\u0631\u0627\u06cc \u06cc\u0627\u0641\u062a\u0646 \u0639\u0636\u0648 \u0645\u0646\u0627\u0633\u0628 \u0648 \u0627\u0646\u062c\u0627\u0645 \u062c\u0631\u0627\u062d\u06cc \u0628\u0633\u06cc\u0627\u0631 \u067e\u0631\u062e\u0637\u0631 \u0627\u0633\u062a \u0648 \u06a9\u0648\u062f\u06a9 \u062f\u0631 \u0627\u06cc\u0646 \u0641\u0627\u0635\u0644\u0647 \u062f\u0631 \u0645\u0639\u0631\u0636 \u062d\u0645\u0644\u0627\u062a \u06a9\u0634\u0646\u062f\u0647 \u0647\u06cc\u067e\u0631\u0622\u0645\u0648\u0646\u0645\u06cc \u0646\u0627\u0634\u06cc \u0627\u0632 \u06a9\u0648\u0686\u06a9\u200c\u062a\u0631\u06cc\u0646 \u0627\u0633\u062a\u0631\u0633 \u06cc\u0627 \u0639\u0641\u0648\u0646\u062a \u0642\u0631\u0627\u0631 \u062f\u0627\u0631\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0628\u0627 \u0627\u06cc\u0646 \u062d\u0627\u0644\u060c \u062f\u0631 \u0633\u0627\u0644 \u06f2\u06f0\u06f2\u06f5\u060c \u062e\u0628\u0631\u06cc \u0645\u0646\u062a\u0634\u0631 \u0634\u062f \u06a9\u0647 \u0627\u0645\u06cc\u062f \u0631\u0627 \u0628\u0647 \u0632\u0646\u062f\u06af\u06cc \u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u0627\u0646 \u0628\u0627\u0632\u06af\u0631\u062f\u0627\u0646\u062f. \u0645\u062d\u0642\u0642\u0627\u0646 \u0628\u06cc\u0645\u0627\u0631\u0633\u062a\u0627\u0646 \u06a9\u0648\u062f\u06a9\u0627\u0646 \u0641\u06cc\u0644\u0627\u062f\u0644\u0641\u06cc\u0627 \u0648 \u062f\u0627\u0646\u0634\u06af\u0627\u0647 \u067e\u0646\u0633\u06cc\u0644\u0648\u0627\u0646\u06cc\u0627 \u0628\u0627 \u062d\u0645\u0627\u06cc\u062a \u0645\u0624\u0633\u0633\u0647 \u0645\u0644\u06cc \u0633\u0644\u0627\u0645\u062a \u0622\u0645\u0631\u06cc\u06a9\u0627 (NIH)\u060c \u0628\u0631\u0627\u06cc \u0627\u0648\u0644\u06cc\u0646 \u0628\u0627\u0631 \u062f\u0631 \u062c\u0647\u0627\u0646 \u062a\u0648\u0627\u0646\u0633\u062a\u0646\u062f \u0628\u0627 \u0627\u0633\u062a\u0641\u0627\u062f\u0647 \u0627\u0632 \u0641\u0646\u0627\u0648\u0631\u06cc \u067e\u06cc\u0634\u0631\u0641\u062a\u0647 \u00ab\u0648\u06cc\u0631\u0627\u06cc\u0634 \u0698\u0646 \u0628\u0627 \u06a9\u0631\u06cc\u0633\u067e\u0631 (CRISPR base editing)\u00bb \u06cc\u06a9 \u062f\u0631\u0645\u0627\u0646 \u0698\u0646\u06cc \u0634\u062e\u0635\u06cc\u200c\u0633\u0627\u0632\u06cc \u0634\u062f\u0647 \u0631\u0627 \u0631\u0648\u06cc \u06cc\u06a9 \u0646\u0648\u0632\u0627\u062f \u0634\u0634 \u0645\u0627\u0647\u0647 \u0645\u0628\u062a\u0644\u0627 \u0628\u0647 \u06a9\u0645\u0628\u0648\u062f CPS1 \u067e\u06cc\u0627\u062f\u0647 \u06a9\u0646\u0646\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0622\u0646\u200c\u0647\u0627 \u0628\u0627 \u0633\u0631\u0639\u062a\u06cc \u0634\u06af\u0641\u062a\u200c\u0627\u0646\u06af\u06cc\u0632 \u0648 \u0637\u06cc \u062a\u0646\u0647\u0627 \u0634\u0634 \u0645\u0627\u0647 \u0627\u0632 \u0632\u0645\u0627\u0646 \u062a\u0634\u062e\u06cc\u0635\u060c \u0627\u0632 \u0633\u0627\u0632\u0645\u0627\u0646 \u063a\u0630\u0627 \u0648 \u062f\u0627\u0631\u0648\u06cc \u0622\u0645\u0631\u06cc\u06a9\u0627 \u0645\u062c\u0648\u0632 \u06cc\u06a9 \u062f\u0631\u0645\u0627\u0646 \u0622\u0632\u0645\u0627\u06cc\u0634\u06cc \u0627\u062e\u062a\u0635\u0627\u0635\u06cc \u06af\u0631\u0641\u062a\u0646\u062f. <\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u062f\u0631 \u0627\u06cc\u0646 \u0631\u0648\u0634\u060c \u0645\u0648\u0644\u06a9\u0648\u0644\u200c\u0647\u0627\u06cc \u0648\u06cc\u0631\u0627\u06cc\u0634\u06af\u0631 \u0698\u0646 \u062f\u0631\u0648\u0646 \u0646\u0627\u0646\u0648\u0630\u0631\u0627\u062a \u0686\u0631\u0628\u06cc \u0645\u062d\u0635\u0648\u0631 \u0634\u062f\u0647 \u0648 \u0627\u0632 \u0631\u0627\u0647 \u0648\u0631\u06cc\u062f \u0628\u0647 \u06a9\u0628\u062f \u062a\u0632\u0631\u06cc\u0642 \u0634\u062f\u0646\u062f \u062a\u0627 \u0645\u0633\u062a\u0642\u06cc\u0645\u0627\u064b \u062c\u0647\u0634 \u0698\u0646\u062a\u06cc\u06a9\u06cc \u062e\u0627\u0635 \u0647\u0645\u0627\u0646 \u0646\u0648\u0632\u0627\u062f \u0631\u0627 \u0627\u0635\u0644\u0627\u062d \u06a9\u0646\u0646\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0646\u062a\u06cc\u062c\u0647 \u062e\u06cc\u0631\u0647\u200c\u06a9\u0646\u0646\u062f\u0647 \u0628\u0648\u062f: \u0638\u0631\u0641 \u0686\u0646\u062f \u0647\u0641\u062a\u0647 \u067e\u0633 \u0627\u0632 \u062a\u0632\u0631\u06cc\u0642\u060c \u06a9\u0648\u062f\u06a9 \u062a\u0648\u0627\u0646\u0633\u062a \u0645\u0642\u062f\u0627\u0631 \u0628\u06cc\u0634\u062a\u0631\u06cc \u067e\u0631\u0648\u062a\u0626\u06cc\u0646 \u062f\u0631 \u0631\u0698\u06cc\u0645 \u062e\u0648\u062f \u062f\u0631\u06cc\u0627\u0641\u062a \u06a9\u0646\u062f \u0648 \u062f\u0648\u0632 \u062f\u0627\u0631\u0648\u0647\u0627\u06cc \u06a9\u0646\u062a\u0631\u0644 \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9 \u06a9\u0627\u0647\u0634 \u06cc\u0627\u0628\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0645\u0647\u0645\u200c\u062a\u0631 \u0627\u0632 \u0647\u0645\u0647\u060c \u0648\u0642\u062a\u06cc \u06a9\u0648\u062f\u06a9 \u0628\u0639\u062f \u0627\u0632 \u062f\u0631\u0645\u0627\u0646 \u062f\u0686\u0627\u0631 \u06cc\u06a9 \u0633\u0631\u0645\u0627\u062e\u0648\u0631\u062f\u06af\u06cc \u0633\u0627\u062f\u0647 \u0634\u062f \u06a9\u0647 \u067e\u06cc\u0634\u200c\u0627\u0632\u0627\u06cc\u0646 \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u0633\u062a \u06cc\u06a9 \u062d\u0627\u062f\u062b\u0647 \u0645\u0631\u06af\u0628\u0627\u0631 \u0628\u0631\u0627\u06cc \u0627\u0648 \u0628\u0627\u0634\u062f\u060c \u0628\u062f\u0646\u0634 \u0628\u062f\u0648\u0646 \u0647\u06cc\u0686 \u0627\u0641\u0632\u0627\u06cc\u0634 \u062e\u0637\u0631\u0646\u0627\u06a9\u06cc \u062f\u0631 \u0622\u0645\u0648\u0646\u06cc\u0627\u06a9\u060c \u0639\u0641\u0648\u0646\u062a \u0631\u0627 \u067e\u0634\u062a \u0633\u0631 \u06af\u0630\u0627\u0634\u062a.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\">\u0627\u06cc\u0646 \u0645\u0648\u0641\u0642\u06cc\u062a \u06cc\u06a9 \u0627\u0646\u0642\u0644\u0627\u0628 \u067e\u0632\u0634\u06a9\u06cc \u0631\u0627 \u0646\u0648\u06cc\u062f \u0645\u06cc\u200c\u062f\u0647\u062f \u06a9\u0647 \u062f\u0631 \u0622\u0646 \u0628\u0647 \u062c\u0627\u06cc \u062f\u0631\u0645\u0627\u0646 \u0639\u0644\u0627\u0645\u062a\u06cc \u06cc\u0627 \u067e\u06cc\u0648\u0646\u062f \u0639\u0636\u0648\u060c \u0645\u06cc\u200c\u062a\u0648\u0627\u0646 \u0628\u0627 \u062f\u0642\u062a \u0645\u0648\u0644\u06a9\u0648\u0644\u06cc\u060c \u062e\u0637\u0627\u06cc \u0698\u0646\u062a\u06cc\u06a9\u06cc \u0631\u0627 \u062f\u0631 \u0645\u062d\u0644 \u062e\u0648\u062f \u0627\u0635\u0644\u0627\u062d \u06a9\u0631\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0627\u06cc\u0646 \u0631\u0648\u0634 \u062f\u0631 \u0648\u0627\u0642\u0639 \u0646\u0645\u0648\u0646\u0647 \u0627\u06cc \u0627\u0632 \u00ab\u0637\u0628 \u0634\u062e\u0635\u06cc \u0633\u0627\u0632\u06cc \u0634\u062f\u0647 \u062f\u0631 \u0645\u0642\u06cc\u0627\u0633 \u06cc\u06a9 \u0646\u0641\u0631 (N-of-1)\u00bb \u0627\u0633\u062a \u06a9\u0647 \u067e\u0644\u062a\u0641\u0631\u0645 \u0622\u0646 \u0642\u0627\u0628\u0644\u06cc\u062a \u0627\u0646\u0637\u0628\u0627\u0642 \u0628\u0627 \u0635\u062f\u0647\u0627 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u0627\u062f\u0631 \u062f\u06cc\u06af\u0631 \u0646\u0627\u0634\u06cc \u0627\u0632 \u062c\u0647\u0634\u200c\u0647\u0627\u06cc \u0645\u0646\u062d\u0635\u0631\u0628\u0647\u200c\u0641\u0631\u062f \u0631\u0627 \u062f\u0627\u0631\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0628\u0627 \u0627\u06cc\u0646 \u062d\u0627\u0644\u060c \u0627\u06cc\u0646 \u062f\u0631\u0645\u0627\u0646 \u0647\u0646\u0648\u0632 \u062f\u0631 \u0645\u0631\u0627\u062d\u0644 \u0627\u0648\u0644\u06cc\u0647 \u062a\u062d\u0642\u06cc\u0642\u0627\u062a\u06cc \u0627\u0633\u062a \u0648 \u0646\u06cc\u0627\u0632 \u0628\u0647 \u067e\u06cc\u06af\u06cc\u0631\u06cc \u0637\u0648\u0644\u0627\u0646\u06cc\u200c\u0645\u062f\u062a \u0628\u0631\u0627\u06cc \u0627\u062b\u0628\u0627\u062a \u0627\u06cc\u0645\u0646\u06cc \u0648 \u0627\u062b\u0631\u0628\u062e\u0634\u06cc \u0622\u0646 \u062f\u0627\u0631\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u062f\u0631 \u062d\u0627\u0644 \u062d\u0627\u0636\u0631\u060c \u062f\u06cc\u06af\u0631 \u0631\u0648\u0634\u200c\u0647\u0627\u06cc \u0698\u0646 \u062f\u0631\u0645\u0627\u0646\u06cc \u0628\u0631\u0627\u06cc \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0646\u0627\u062f\u0631 \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u06a9 \u0645\u0627\u0646\u0646\u062f \u0622\u062a\u0631\u0648\u0641\u06cc \u0639\u0636\u0644\u0627\u0646\u06cc \u0646\u062e\u0627\u0639\u06cc (SMA) \u0648 \u0633\u0646\u062f\u0631\u0645 \u0648\u0627\u06cc\u0633\u06a9\u0627\u062a-\u0622\u0644\u062f\u0631\u06cc\u0686 \u0646\u06cc\u0632 \u062a\u0623\u06cc\u06cc\u062f \u0634\u062f\u0647\u200c\u0627\u0646\u062f \u06a9\u0647 \u0647\u0645\u06af\u06cc \u0627\u0645\u06cc\u062f \u0628\u0647 \u0631\u06cc\u0634\u0647\u200c\u06a9\u0646\u06cc \u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc \u0635\u0639\u0628\u200c\u0627\u0644\u0639\u0644\u0627\u062c \u0631\u0627 \u0628\u06cc\u0634 \u0627\u0632 \u067e\u06cc\u0634 \u06a9\u0631\u062f\u0647\u200c\u0627\u0646\u062f.<\/span><\/p>\n<p style=\"text-align: justify;\"><span style=\"font-size: 14pt; color: #000000;\"> \u0628\u0631\u0627\u06cc \u062e\u0627\u0646\u0648\u0627\u062f\u0647\u200c\u0647\u0627\u06cc\u06cc \u06a9\u0647 \u0628\u0627 \u062a\u0634\u062e\u06cc\u0635 \u06a9\u0645\u0628\u0648\u062f CPS1 \u06cc\u0627 \u0647\u0631 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u0627\u062f\u0631 \u0645\u0634\u0627\u0628\u0647\u06cc \u0631\u0648\u0628\u0631\u0648 \u0645\u06cc\u200c\u0634\u0648\u0646\u062f\u060c \u067e\u06cc\u06af\u06cc\u0631\u06cc \u0645\u0634\u0627\u0648\u0631\u0647 \u0698\u0646\u062a\u06cc\u06a9 \u0648 \u062b\u0628\u062a\u200c\u0646\u0627\u0645 \u062f\u0631 \u06a9\u0627\u0631\u0622\u0632\u0645\u0627\u06cc\u06cc\u200c\u0647\u0627\u06cc \u0628\u0627\u0644\u06cc\u0646\u06cc \u0698\u0646 \u062f\u0631\u0645\u0627\u0646\u06cc \u0645\u06cc\u200c\u062a\u0648\u0627\u0646\u062f \u06cc\u06a9 \u06af\u0632\u06cc\u0646\u0647 \u0627\u0645\u06cc\u062f\u0628\u062e\u0634 \u0628\u0631\u0627\u06cc \u062a\u063a\u06cc\u06cc\u0631 \u0645\u0633\u06cc\u0631 \u0632\u0646\u062f\u06af\u06cc \u0628\u0627\u0634\u062f.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u0622\u0628\u062a\u0627\u0628: \u062f\u06a9\u062a\u0631 \u0645\u062d\u0645\u062f\u0639\u0644\u06cc \u0635\u0627\u0631\u0645\u06cc\u060c\u00a0\u062f\u0631 \u0645\u06cc\u0627\u0646 \u0647\u0632\u0627\u0631\u0627\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0646\u0627\u062f\u0631 \u0698\u0646\u062a\u06cc\u06a9\u06cc \u06a9\u0647 \u0647\u0631 \u06cc\u06a9 \u0628\u0647 \u062a\u0646\u0647\u0627\u06cc\u06cc \u062a\u0639\u062f\u0627\u062f \u0645\u062d\u062f\u0648\u062f\u06cc \u0627\u0632 \u0627\u0641\u0631\u0627\u062f \u0631\u0627 \u062f\u0631 \u0633\u0631\u0627\u0633\u0631 \u062c\u0647\u0627\u0646 \u062a\u062d\u062a \u062a\u0623\u062b\u06cc\u0631 \u0642\u0631\u0627\u0631 \u0645\u06cc\u200c\u062f\u0647\u0646\u062f\u060c \u00ab\u06a9\u0645\u0628\u0648\u062f \u0622\u0646\u0632\u06cc\u0645 \u06a9\u0631\u0628\u0627\u0645\u0648\u0626\u06cc\u0644 \u0641\u0633\u0641\u0627\u062a \u0633\u0646\u062a\u062a\u0627\u0632 \u06f1\u00bb \u06cc\u0627 \u0628\u0647 \u0627\u062e\u062a\u0635\u0627\u0631 CPS1 deficiency \u06cc\u06a9\u06cc \u0627\u0632 \u067e\u06cc\u0686\u06cc\u062f\u0647\u200c\u062a\u0631\u06cc\u0646 \u0648 \u062e\u0637\u0631\u0646\u0627\u06a9\u200c\u062a\u0631\u06cc\u0646 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0645\u062a\u0627\u0628\u0648\u0644\u06cc\u06a9 \u0645\u062d\u0633\u0648\u0628 \u0645\u06cc\u200c\u0634\u0648\u062f. \u0627\u06cc\u0646 \u0628\u06cc\u0645\u0627\u0631\u06cc \u0628\u0647 \u062f\u0633\u062a\u0647\u200c\u0627\u06cc \u0627\u0632 \u0627\u062e\u062a\u0644\u0627\u0644\u0627\u062a \u0628\u0647 \u0646\u0627\u0645 \u00ab\u0628\u06cc\u0645\u0627\u0631\u06cc\u200c\u0647\u0627\u06cc 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